rheumatology-congress-physiology-2019-posters-abstracts

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December 9-10, 2019 | Barcelona, Spain

Volume 14

ARTHRITIS AND RHEUMATOLOGY

ANATOMY AND PHYSIOLOGY

International Conference on

Journal of Orthopaedics Trauma Surgery

and Related Research

Rheumatology Congress 2019 & Anatomy and Physiology 2019

December 09-10, 2019

J Orthop Trauma Surg Rel Res, ISSN: 1897-2276

The effects of neurokin1 receptor antagonist for arthritic pain in a rat model of

osteoarthritis

Dongyeon Nam, Jinju Kwon, Jinseung Lee, Junesun Kim

Korea University, South Korea

Statement of the Problem

: Osteoarthritis (OA) cause inflammation in the joint and is a common degenerative disease in elderly

people. Chronic pain is a main symptom in OA patients. However, medications for OA pain limited effects due to the side effects

depending on long- lasting usage. Substance P is a neuropeptide release from nociceptive afferent fiber to peripheral and central

nervous system that is responsible for neurogenic inflammation and pain transmission through the activation of neurokinin 1

(NK1) receptor. This study was designed to examine a possibility for the NK1 receptor antagonist to be a therapeutic agent for

OA pain.

Methodology & Theoretical Orientation

: Knee joint inflammation was induced by intra-articular injection of monosodium

iodoacetate (MIA, 2mg/50ul). NK1 receptor antagonist (TOCRIS, GR92334, 10uM/30ul) injected before (Pre group) and after

MIA injection (Post group). To assess edema, the knee joint diameter was measured by caliper. Paw withdrawal threshold

(PWT) was used by von Frey filament to measure mechanical hypersensitivity, and weight bearing test, knee bending test were

performed to evaluate the pain during knee joint move.

Findings

: Both pre- and post-administration of NK1 receptor antagonist significantly

reduced edema in ipsilateral hind-limb on days 2 and 3 after MIA injection.

Significant decrease of PWT caused in the MIA group was observed from days 10.

However, a single injection of NK1 receptor antagonist into the knee joint inhibited

to develop mechanical allodynia in both PRE and POST groups. However, NK1

receptor antagonist in both PRE and POST group did not produce any significant

changes in reduced weight bearing and increased knee joint score on the ipsilateral

hind-limb after MIA injection compared with the MIA only group. Conclusion &

Significance: Administration of NK1 receptor antagonist in early stage of OA

inhibited the initiation of chronic pain through alleviation of inflammatory responses

in the joints.

Biography

Junesun Kim is P.T. and Ph.D. in Physiology. She is a professor at Department of Physical Therapy Korea University College of

Health Science. Her major fields of academic interest are the peripheral and central mechanisms of chronic pain, and regenerative

mechanisms governing spinal cord injury. She has several publications in in peer-reviewed journals. She provides continuing education

lectures regarding neurological physical therapy for SCI and mechanisms of chronic and pathologic pain to student majoring in

rehabilitation science at graduate program.