rheumatology-congress-physiology-2019-posters-abstracts

Page 42

December 9-10, 2019 | Barcelona, Spain

Volume 14

ARTHRITIS AND RHEUMATOLOGY

ANATOMY AND PHYSIOLOGY

International Conference on

Journal of Orthopaedics Trauma Surgery

and Related Research

Rheumatology Congress 2019 & Anatomy and Physiology 2019

December 09-10, 2019

J Orthop Trauma Surg Rel Res, ISSN: 1897-2276

Establishment and cryopreservation of humanmesenchymal stemcells fromwharton’s

jelly of umbilical cord

Nadeem G

Ajman University, UAE

Introduction

: Stem cells are special human cells that have the ability to develop into many different cell types and also have the

ability to repair damaged tissues. Mesenchymal stem cells (MSCs) are currently considered as ‘Medicinal Signaling Cells’ and a

promising resource in regard to cell-based regenerative therapy. Umbilical cord is a human term perinatal tissue which is easily

attainable, and a promising source of stem cells with no associated ethical concerns.

Material and Method

: Wharton’s jelly (WJ) is the gelatinous matrix that surrounds and provides protection to the umbilical cord

blood vessels. Beingmore primitive, MSCs fromhuman umbilical cord exhibit greater proliferative capacity and immunosuppressive

ability. Thus as compared to adult stem cells it gives them a therapeutic advantage.

Conclusion

: Being a primitive stromal cell population, WJ-MSCs offer the advantage of faster proliferation rate and reduced

immunogenicity as compared to adult tissue derived MSCs. Hence, successful isolation of robustly proliferating healthy MSCs from

WJ of human umbilical cord, which retain all the basic MSC properties, assumes importance.