rheumatology-congress-physiology-2019-keynote

Page 12

December 9-10, 2019 | Barcelona, Spain

Journal of Orthopaedics Trauma Surgery

and Related Research

ARTHRITIS AND RHEUMATOLOGY

ANATOMY AND PHYSIOLOGY

International Conference on

J Orthop Trauma Surg Rel Res, ISSN: 1897-2276

Rheumatology Congress 2019 & Anatomy and Physiology 2019

December 09-10, 2019

Volume 14

Effect of methyltrienolone on the metabolic disorders in rat model of Alloxan-

induced diabetes

Aim

: The aimof the studywas to investigate the restoration of metabolic imbalance relatedwith deficiency of insulin by the exogenous

androgen supplementation in the experimental model of alloxan-induced diabetes in Wistar male rats.

Methods

: The experimental diabetes was induced by a single intraperitoneal administration of alloxan. The concentrations of glucose,

immunereactive insulin, corticosterone, testosterone and estradiol were examined in blood, the intensity of DNA and RNA synthesis

and androgen receptor expression were studied in the liver tissue – at 15th, 30th and 45th days of alloxan-induced diabetes. The

synthetic androgen methyltrienolone was administered to rats with 30-days diabetes during 15 days.All data were compared to control

group received solvent.

Results

: The induction of diabetes increased the concentrations of glucose, corticosterone and estradiol while decreases insulin

and testosterone concentration in blood as well as DNA/RNA synthesis and androgen receptors expression in hepatocytes. The

administration of exogenous androgen significantly restored the metabolic imbalance and the expression of androgen receptors and

increased DNA/RNA synthesis in liver cells maintained close to control level.

Conclusion

: The administration of methyltrienolone reduced the effect of “diabetic stress” and restored the hormonal dysfunction

induced by alloxan.

Biography

Davit Tophuria is the Dean of International Faculty of Medicine of Tbilisi State Medical University, Senior Specialist of University Strategy

Development in DAUG University and Vice-Principal in Education and Science in Dimitry Kipiani School from 2004-2007.Assoc. Professor of

Human Normal Anatomy Head of International Students Academic Department from 2007-till now, He has done 85 International Publications

and attended 25 International Conferences.

Davit Tophuria

Tbilisi State Medical University, Georgia