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Volume 13
Journal of Orthopaedics Trauma Surgery and Related Research
ISSN: 1897-2276
Orthopedics 2018
March 08-09, 2018
March 08-09, 2018 London, UK
10
th
International Conference on
Orthopedics, Trauma and Rheumatology
Bryonia alba
L., a new approach to rheumatic diseases
Mert Ilhan
1,2
, Fatma Tugce Guragac
1
and Esra Küpeli Akkol
1
1
Gazi University, Turkey
2
Yuzuncu Yıl University, Turkey
B
ryonia alba
L. (Cucurbitaceae) has been used to treat rheumatic pain in Turkish folk medicine. According to phytochemical
investigations, it has been found to have cucurbitacins and some flavone C-glycosides. Antioxidant, anti-inflammatory and
anti-nociceptive activities of
B. alba
were investigated in this study. n-hexane, ethyl acetate and methanol extracts were prepared
from
B. alba
roots, successively. For the evaluation of anti-inflammatory, anti-nociceptive activities of these extracts, carrageenan-
induced hind paw edema, acetic acid-induced increased vascular permeability, p-benzoquinone induced writhing, tail flick tests were
performed. DPPH, ABTS, non-site-specific hydroxyl radical scavenging activity and FRAP assays were used for the assessment of
antioxidant activity for the extracts. According to the results, the ethyl acetate extract showed the potent anti-inflammatory activity
on both anti-inflammatory mice models and also the same extract displayed statistically significant activity on p-benzoquinone
induced writhing model. Furthermore, total phenolic and total flavonoid content assays were conducted on ethyl extract of
B. alba
roots which have the highest anti-inflammatory and anti-nociceptive activity among tested extracts. As a result, ethyl acetate extract
of
B. alba
roots could be used for the treatment of inflammatory diseases.
Biography
Mert Ilhan has received his BS degree from Faculty of Pharmacy, Ankara University, Turkey and pursuing his PhD studies in the Department of Pharmacognosy,
Faculty of Pharmacy, Gazi University with Professor Esra Akkol. He has 13 published articles in SCI indexed journals and 1 chapter in international book.
mertilhan@gazi.edu.trMert Ilhan et al., J Orthop Trauma Surg Rel Res 2018, Volume 13