Painful intervertebral disc degeneration

Low Back Pain (LBP) is a common musculoskeletal illness that causes significant social and economic consequences. It is the main cause of disability. Inflammation and associated signaling pathways have recently been recognized as critical roles in the start and progression of disc degeneration, a major contributor to LBP. Inflammatory mediators are also important in the development of discogenic LBP. LBP suppression is a main goal of therapeutic management, but disc research studies haven't paid enough attention to it. A discussion of the function of inflammation in IVD degeneration and pain induction is included in this summary of advancements in inflammation-related pain in disc degeneration. Puncture models, mechanical models, and spontaneous models are presented as the principal animal models for studying painful disc degeneration, as well as the underlying signaling pathways. Furthermore, promising medication candidates for suppressing discogenic LBP by reducing inflammation are investigated, either in the lab or in clinical trials.