Linking elements in the musculoskeletal framework: Tendons and ligaments

The musculoskeletal system, which includes bones, muscles, and connective tissues such as cartilage, tendons, and ligaments, is essential for providing the body with structure, support, protection for vital organs, and the ability to move. Tendons and ligaments are particularly important for movement, as they connect muscles to bones and bones to each other. Damage to tendons and ligaments, whether from acute or chronic injury, aging, or arthritis, is a common source of impairment. Improving therapeutic options for these conditions requires a more comprehensive understanding of the development, cell biology, and pathophysiology of tendons and ligaments. Despite their critical role in musculoskeletal function and disease, research on tendons and ligaments is not as advanced as that on other skeletal tissues. This is partly because the transcription factors necessary for the development and maintenance of these tissues have only recently been identified. A greater focus on the study of tendons and ligaments could lead to significant advancements in treatments for related disorders, ultimately improving quality of life for individuals affected by these conditions. Understanding the unique aspects of tendon and ligament biology is crucial for developing targeted therapies and addressing the specific challenges posed by injuries and degenerative conditions affecting these connective tissues.